About Spravato®

The first nasal spray medication for treatment-resistant depression.

Ketamine is a medication that has been used as a surgical anesthesia around the world for more than 50 years with children, adults, and animals.  About 20 years ago, ketamine’s ability to relieve depression, anxiety, and some pain disorders in less than 24 hours after administration was stumbled upon by researchers. Follow-up studies replicating the rapid results have changed researchers’ understanding of depression, revitalizing an area of medical research that had been stagnant for almost three decades.

Esketamine, or Spravato, is derived from ketamine and makes powerful antidepressant relief available to be delivered intra-nasally, similar to a common nasal decongestant. We offer esketamine therapy, and this novel therapy for treatment-resistant depression can be combined with other treatment modalities, such as antidepressants, Transcranial Magnetic Stimulation (TMS), or other therapies.

Is Spravato® right for me?

Our doctors are experts at evaluating your specific needs and the medications you have tried in the past. During your initial evaluation, we will review your medical history and together map out a treatment plan that is best for you.

Esketamine, or Spravato, is the first nasal spray medication that is a treatment for depression. Combined with an antidepressant, Spravato is FDA-approved to treat depression and has been clinically shown to improve symptoms of depression over just 4 weeks.

At our office, the patient will administer the Spravato treatment spray under the supervision of one of our healthcare providers. Afterwards, there is a two-hour observation window to monitor for side effects.

Unlike antidepressants, which need to be taken every day, Spravato is only administered a couple of times each week: Two treatments per week for the first month, then one treatment per week for the second month, and one treatment every two weeks for subsequent months.

Esketamine therapy patients generally report some sedation and disassociation effects during or shortly after the administration of the drug. Other side effects may include nausea, dizziness, vertigo, or headache.

Spravato has been FDA-approved since 2019 and evaluated in both short- and long-term trials for safety and efficacy. Because Spravato is administered in our office, patients will be monitored closely for any adverse side effects.

Before starting esketamine therapy, we will discuss all potential side effects and interactions, and make sure Spravato is right for you.

What Should I expect during treatment?

  • Plan to be at our office for 2.5 hours.
  • No food for 2 hours before treatment.
  • You can have fluid up to 30 minutes before treatment.
  • You must have someone pick you up and drive you home after treatment.
  • During treatment you are resting comfortably and being closely monitored by our medical team.
  • You can take your regular medications with a sip of water but you need to avoid taking any benzodiazepine medication such as: Xanax, Klonopin, Ativan or Valium on the day of treatment.